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Redox Sensitive MR Contrast Agent
Author(s) -
Matsumoto Kenichiro,
Nakanishi Ikuo,
Anzai Kazunori
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb489
Subject(s) - redox , nitroxyl , nitroxide mediated radical polymerization , chemistry , electron paramagnetic resonance , radical , photochemistry , paramagnetism , in vivo , nuclear magnetic resonance , inorganic chemistry , biochemistry , organic chemistry , polymer , physics , microbiology and biotechnology , radical polymerization , quantum mechanics , copolymer , biology
Nitroxyl radicals (also known as nitroxide) have been used as in vitro and in vivo redox probes in fields of electron paramagnetic resonance (EPR) spectroscopy and imaging. Nitroxyl radicals are paramagnetic species, which also can be detected using T 1 ‐weighted MRI. Reactive oxygen species (ROS) react with nitroxyl radicals to lose paramagnetism. The time course of in vivo MRI intensity induced by a nitroxyl radical can give tissue redox information, which is the so called the redox imaging technique. Employing a membrane permeable nitroxyl radical, redox information in tissues could be available. A brief theory of redox imaging techniques and applications of redox imaging techniques are introduced.