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Synthesis of some new derivates of [(heteroaryl‐2‐ylimino)‐ethyl]‐benzopyran‐2ones and their antimicrobial activity
Author(s) -
Selmani Pranvera Breznica,
Hoti Ramiz,
MulliqiOsmani Gjyle,
DamoniRexha Dafina,
Gashi Fatbardh
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb488
Subject(s) - antimicrobial , candida albicans , chemistry , benzopyran , condensation , catalysis , zinc , nuclear chemistry , organic chemistry , microbiology and biotechnology , biology , physics , thermodynamics
Novel derivates of 3‐[1‐(pyridin‐2‐ylimino)‐ethyl]‐benzopyran‐2‐ones 3(a–c) and 3‐[1‐(pyrimidin‐2‐ylimino)‐ethyl]‐benzopyran‐2‐ones 3(d–e) are synthesized by condensation reactions of 3‐acetyl‐benzopyiran‐2‐one 2 with corresponding heterocyclic amines 2(a–e). These products are synthesized by catalytic reactions using zinc chloride, in reflux conditions. Products are characterized on the basis of their spectroscopic data. Antimicrobial activity of products 4(a–e) against S. aureus, E. coli and Candida albicans are investigated measuring inhibition zones around disks marked previously with corresponding compounds. Results are shown for a considerable activity of products against these microorganisms