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Effects of exendin in rats trained to discriminate between 22 and 2 hr food deprivation
Author(s) -
Jewett David C.,
Dunbar Andrew,
Faile Shan,
Green Ryan,
Bauer Dana,
Bolek Barbara
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb457
Subject(s) - stimulus control , agonist , stimulus (psychology) , endocrinology , medicine , energy expenditure , food intake , saline , psychology , receptor , nicotine , psychotherapist
Previous research had demonstrated that GLP‐1 agonists decrease food intake and energy expenditure. Previously we have found that drugs that alter energy expenditure also alter the discriminative stimulus effects of 22 hr food deprivation in rats. We tested the effects of exendin‐4, a GLP‐1 agonist, in rats trained to discriminate 22 hr food deprivation from 2 hr food deprivation in a two‐lever, operant choice task. After rats acquired the discrimination, subjects were food restricted for 22 hr and administered saline or exendin‐4 (0.1–0.56 mcg/kg, i.p.). Thirty min later, the discriminative stimulus effects were assessed. Exendin‐4 did not alter the discriminative stimulus effects of 22 hr food deprivation. A larger dose (1.0 mcg/kg) eliminated responding and significantly decreased food intake. While exendin‐4 decreases intake and rate of responding, exendin‐4 did not alter the “hunger” discrimination.