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Increase of the antidepressant action of desipramine caused by caffeine and amphetamine
Author(s) -
VILLAFAÑA SANTIAGO,
ROBLESMOLINA EVELYN,
MILLAN DANIEL,
HONG ENRIQUE,
HUANG FENGYANG
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb455
Subject(s) - desipramine , antidepressant , amphetamine , caffeine , pharmacology , serotonin , chemistry , medicine , endocrinology , dopamine , receptor , hippocampus
Desipramine is an antidepressive agent widely used which acts through the inhibition of the recapture of noradrenaline and serotonin, on the other hand, central stimulants such as caffeine and amphetamine help to release noradrenaline and serotonin, for this reason the combination of these agents with desipramine could increase the antidepressant response to desipramine, The aim of this work was to evaluate the antidepressive response of desipramine when its combine with caffeine and amphetamine in the forced swimming model. Male mice were used they received different doses of desipramine, caffeine, amphetamine, desipramine‐caffeine and desipramine‐amphetamine. The results showed that all agents produce immobility time decreased. When performing dose combinations without antidepressant effect of caffeine and amphetamine with desipramine was observed an increase in antidepressant response to desipramine, presenting only the combination of desipramine‐amphetamine on motor activity changes. These results suggest that drugs that promote the release of noradrenaline and serotonin could be used in combination with antidepressants to increase its effect, especially caffeine.