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Evaluation of complementary treatment in DMBA breast cancer model – preliminary results
Author(s) -
Cabrita Antonio Silverio,
Verrier Guido
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb447
Subject(s) - dmba , medicine , breast cancer , histopathology , statistical significance , cancer , oncology , breast carcinoma , statistical analysis , carcinogenesis , pathology , statistics , mathematics
Over the last decade, conventional breast cancer therapies have been frequently adjuvated with complementary medicine techniques (CMT). In spite of medical evidence, experimental models are required to validate CMT effect on breast cancer. This study has two groups of nine Sprague‐Dawley female rats. They were orally given a single dose of DMBA (65 mg/Kg) at one month of age according to the breast cancer protocol. One group (I) was maintained with no other treatment for 24 weeks. The other group (II) was submitted to hands on treatment, three times a week, 15 minutes each, during 24 weeks. All the survival animals were ethically euthanized 24 weeks after carcinogenesis induction. The malignant breast tumors were evaluated by histopathology. Statistical analysis was carried out using a χ2 and Fisher's tests. The level of significance was set at P< 0,05. There was no statistical difference between the morphology of both groups. This preliminary study suggests that CMT has no effect on breast carcinoma morphology, although further studies are required to evaluate an action on patient condition.