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The protective effect of bee venom against ethanol‐induced hepatic injury via regulation of the mitochondria‐related apoptotic pathway
Author(s) -
Park KwanKyu,
Park JiHyun,
Kim KyungHyun,
Kim SooJung,
Lee WooRam,
Han Sangmi,
Lee Kwanggil
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb404
Subject(s) - apoptosis , hepatocyte , venom , chronic liver disease , poly adp ribose polymerase , pharmacology , programmed cell death , liver disease , medicine , immunology , biology , biochemistry , in vitro , cirrhosis , polymerase , gene
Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom ( Apis mellifera ) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. However, the precise mechanism for bee venom in chronic liver disease is not still cleared. To assess the effects of bee venom in chronic liver disease, we investigated the potential role of the bee venom in the ethanol‐induced hepatocyte apoptosis. Bee venom treatment inhibited the apoptotic cell morphology and increased cell viability in ethanol‐induced hepatocyte apoptosis. With ethanol treatment, bee venom treated hepatocytes increased activity of Bcl‐2 and Bcl‐xL, reduced activity of Bax, Caspase and PARP. In conclusion, bee venom treatment in ethanol‐induced hepatocyte apoptosis occurred through the regulation of Bcl‐family with subsequent inactivation of the Caspase and PARP. These results suggest that bee venom could be an effective agent to reduce ethanol‐induced hepatocyte apoptosis. This work was supported by a grant (2007030103400101) from Biogreen 21 Program, Rural Development Administration, Republic of Korea.