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Added sugars in diet and risk of total and cause‐specific mortality in a large US cohort
Author(s) -
Tasevska Natasa,
Park Yikyung,
Subar Amy F.,
Schatzkin Arthur,
Potischman Nancy
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb391
Subject(s) - medicine , hazard ratio , proportional hazards model , confidence interval , cohort , diabetes mellitus , incidence (geometry) , cohort study , demography , endocrinology , physics , optics , sociology
Consumption of added sugars is increasing worldwide and parallels the global rising prevalence of chronic diseases such as cancer, cardiovascular (CVD) and type 2 diabetes. Although previous studies have linked added sugars intake with incidence of these diseases, its association to mortality is unknown. Participants (n=435,674) aged 50 – 71 years from the NIH‐AARP Diet and Health Study with no history of major chronic disease at baseline were followed‐up for 10 years. Intake of added sugars was assessed at baseline using a 124‐item food frequency questionnaire. Hazard ratios (HR) and 95% confidence intervals (CI) for total mortality and mortality of cancer and CVD were estimated in multivariable models adjusted for potential risk factors using Cox proportional hazards regression. We identified 18,904 deaths in men and 9,786 deaths in women. After multivariable adjustment, intake of added sugars was no longer positively associated with the risk of total mortality in either men (P trend = 0.37) or women (P trend = 0.11). The investigation of cause‐specific mortality revealed only weak inverse association between added sugars and risk of CVD in men (HR Q5 vs Q1 = 0.85; 95%CI = 0.77 – 0.93; P trend = 0.008). In this US cohort, added sugars were not associated with all‐cause mortality, and only showed a weak protective effect for CVD in men. Supported by the Intramural Research Program of the U.S. DHHS NIH/NCI.