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25‐hydroxyvitamin D response to a single vitamin D3 dose in pregnant and non‐pregnant women: a pharmacokinetic study in Dhaka, Bangladesh
Author(s) -
Roth Daniel E,
AlMahmud Abdullah,
Roy Eliza,
El Arifeen Shams,
Raqib Rubhana,
Black Robert E.,
Baqui Abdullah H.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb341
Subject(s) - cmax , pharmacokinetics , medicine , bioavailability , percentile , vitamin d and neurology , vitamin , pregnancy , gestation , cholecalciferol , zoology , endocrinology , pharmacology , mathematics , biology , statistics , genetics
Changes in serum 25‐hydroxyvitamin D concentration (Δ[25(OH)D]) in response to a single oral dose of 70,000 IU vitamin D3 were characterized in two groups of women in Dhaka: non‐pregnant (NP; N=18) and 30‐weeks pregnant (P; N=13). Six serial blood samples were collected from each participant (up to day 56 or 70 post‐dose). Pharmacokinetic parameters aggregated by group included mean (± standard deviation, SD) maximum [25(OH)D] rise above baseline (ΔCmax), median days to ΔCmax (Tmax), and mean, 5 th , 50 th , and 95 th percentiles of the positive area‐under‐the‐Δ[25(OH)D]‐time curve to 28 days (AUC28). Mean baseline [25(OH)D] was lower in P, but mean ΔCmax was similar in P and NP. Average AUC28 was slightly larger in P, but the overall distributions were similar.Parameter Non‐pregnant PregnantBaseline [25(OH)D] (nmol/L) Mean ±SD 56 ±22 46 ±20 Δ Cmax (nmol/L) Mean ±SD 35 ±21 37 ±14Tmax (days) Median 7 21AUC28 (nmol · day/L) Mean ±SD 588 ±342 683 ±321 Percentiles 25 th 377 382 50 th 496 768 75 th 819 877There was high inter‐subject variability in [25(OH)D] responses, but averages were consistent with published single‐dose pharmacokinetic vitamin D3 studies in non‐pregnant adults. There was no strong evidence that pregnancy influences the peak rise in [25(OH)D] after a dose of vitamin D3, but larger studies are required to establish whether small observed differences in bioavailability are reproducible and biologically relevant.