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Retrospective assessment of growth in infants exposed to HIV in utero
Author(s) -
Manion Erika,
Jones Lauren,
Lawrence Robert,
Borum Peggy R.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb324
Subject(s) - medicine , population , pediatrics , in utero , retrospective cohort study , birth weight , standard score , human immunodeficiency virus (hiv) , demography , pregnancy , immunology , biology , mathematics , environmental health , fetus , statistics , sociology , genetics
The objective of the study was to evaluate growth in uninfected infants exposed to HIV. This retrospective study was approved by the UF Institutional Review Board. Infants exposed to HIV enrolled from 1997 to 2009 in the UF Pediatric Immunology Program (n=198) were stratified into 5 age groups ranging from birth to 24 months in age. An average height, weight, and BMI z‐score were calculated and compared to the 2000 CDC growth charts and WHO growth charts reference populations. The student's t test was conducted using the Palaside StatTools Program and SAS 9.2. The table below compares mean z‐scores of the exposed infant population to the mean z‐scores of the reference population. Height and weight z‐scores of this infant population are both below that of the reference population, but demonstrate different patterns of change during the first 24 months of life. Linear growth is stunted in infants exposed to HIV in utero. The BMI z‐score of this infant population is significantly larger than the reference population mean after 4 months of age. The growth of exposed infants should be followed more carefully and for a longer period of time.Height Weight BMIBirth −0.698 ** −0.961 ** −0.683 ** 0–3 Months −1.121 ** −0.781 ** −0.382 ** 4–6 Months −0.581 ** −0.173 0.209 * 7–12 Months −0.326 ** −0.303 * 0.333 * 13–24 Months −0.233 * −0.323 ** 0.771 *** p<0.05** p<0.01