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Comparison of Various Preparations of Gynostemma pentaphyllum (Jiaogulan) and its Main Active Constituents, Gypenoside Saponins, on Resting Metabolic Rate: Controlled Human Clinical Study
Author(s) -
Amagase Harunobu,
Handel Richard
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb264
Subject(s) - codonopsis , gynostemma pentaphyllum , chemistry , traditional medicine , schisandra chinensis , rhodiola , saponin , food science , botany , biology , medicine , extraction (chemistry) , salidroside , traditional chinese medicine , chromatography , alternative medicine , pathology
We have compared efficacies of 3 different Gynostemma pentapyllum (jiaogulan) samples on resting metabolic rate (RMR) by hand‐held indirect calorimeter in healthy human adults (n=10). The samples were jiaogulan leaf extract ( A ), jiaogulan blend composed of extracted and freeze‐dried whole Gynostemma plant ( B ), and JULE of the Orient TM (JULE), an herbal blend consisting of B plus goji, astragalus, codonopsis, jujube, longan, luohanguo, rhodiola, schisandra, açai, amalaki, aronia, camu‐camu, elderberry, ginger, Japanese sophora, blueberry, bilberry, lychee, cranberry, cherry and reishi mushroom. Total saponins were adjusted at the same level in all samples. Each sample (60 ml) was separately consumed immediately before a nutritional beverage (360 kcal) after 12 h fast. B increased RMR by 178 kcal over baseline level (1,703 kcal) at 2 h post‐intake. JULE intake further increased RMR by 231 kcal significantly (P<0.05), about 14% of baseline level. A increased RMR by 134 kcal over baseline, which was same level with control (139 kcal), and was significantly lower than the effect of B or JULE. These results suggest that constituents other than saponins in jiaogulan may have stimulating effects on metabolism, that whole plant jiaogulan may have greater efficacies than leaf alone, and that the synergistic effect of various herbs in the JULE causes significant increase in the effect of jiaogulan on human metabolism.