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PHOSPHORYLATION REGULATION OF MIXED LINEAGE LEUKEMIA 5
Author(s) -
Deng Lih Wen,
Liu Jie
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb152
Subject(s) - cell cycle , phosphorylation , biology , microbiology and biotechnology , chromatin , epigenetics , cell , haematopoiesis , cell growth , cancer research , gene , genetics , stem cell
The human Mixed Lineage Leukaemia‐5 (MLL5) gene is frequently deleted in myeloid malignancies. Emerging evidence suggest that MLL5 has important functions in adult hematopoiesis and chromatin regulatory network, and participates in regulating the cell cycle machinery. To further investigate its cellular regulatory functions, we studied the expression and post‐translational modification of MLL5 throughout the cell cycle. Our results demonstrated that MLL5 is regulated by cell cycle‐dependent phosphorylation, and reduced phosphorylation modification of MLL5 is associated with the inhibition of cell cycle progression. Our data provides a molecular foundation for further investigation on the mechanisms of cell cycle transition or epigenetic regulatory role of MLL5 with the phosphorylation signalling network.