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The Ser377Gly of the GATA4 gene is a susceptibility variant for hypertension
Author(s) -
Alrasheed Maha M,
Muiya Paul,
Gueco Daisy,
Andres Editha,
Alshahid Maie,
Dzimiri Nduna
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb135
Subject(s) - medicine , confounding , odds ratio , diabetes mellitus , myocardial infarction , confidence interval , coronary artery disease , single nucleotide polymorphism , disease , cardiology , endocrinology , gene , genetics , genotype , biology
The disease‐predisposing effect of GATA4 to acquiring cardiovascular disease still remains to be elucidated. We initially sequenced the GATA4 coding region to identify variants of interest in a total of 250 individuals, and investigated the impact of 5 SNPs, rs3729855 (C>T), rs3729856 (A>G), rs1062219 (C>T), rs11785481 (C>T) and rs3203358 (C>G) on myocardial infarction (MI) by the real‐time PCR‐based techniques in a total of 3969 Saudi individuals. We first tested the potential confounding impact of congenital heart disease (CHD) on the study by comparing the 113 CHD patients versus 272 individuals harbouring dilated cardiomyopathy DCM. The results pointed to a significant causative association for the rs3729856 (p.S377G) with CHD [Odds ratio(95% Confidence Interval) = [1.76(1.18–2.61); p=0.005]. We further compared the 113 CHD versus the rest of the individuals (3969) and observed a similarly significant association [1.43(1.04–1.97); p=0.026]. Therefore, in order to rule out the influence of CHD on other relationships, we excluded the CHD individuals from further analyses, involving 2926 hypertensive patients (HTN) and 1022 non‐hypertensive individuals. Interestingly, the rs3729856 [1.22(1.06–1.40); p=0.005] similarly conferred risk for HTN. None of the other SNPs was associated with the disease and no confounding effect of coronary artery disease, diabetes of dyslipidaemia was found. These results demonstrate that the GATA4 rs3729856 (A>G) variant independently predisposes individual to acquiring CDH and HTN.