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Striking and Preferential Expression of ADRM1 (adhesion regulating molecule1) in Colon, and Lung Cancers
Author(s) -
Cha MeeKyung,
Kim IlHan
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb133
Subject(s) - proteasome , biology , colorectal cancer , cancer research , cell adhesion , cancer , cell growth , lung cancer , gene expression , cell cycle , cell , lung , gene , microbiology and biotechnology , medicine , genetics
The proteasome is a multiprotein complex that regulates the stability of hundreds of cellular proteins and thus, it is implicated in virtually all cellular functions such as the regulation of cell proliferation or cell cycle control, transcriptional regulation, immune and stress response, cell differentiation, and apoptosis. ADRM1 (adhesion regulating molecule1) is a known component of the proteasome. As for some other proteasome subunits, its exact role is not clearly known. ADRM1 is abundant and widely distributed both phylogenetically and in tissues. We investigated levels of expression of ADRM1 gene in various cancer tissues by real‐time polymerase chain reaction. Levels of ADRM1messenger RNA (mRNA) in colon and lung cancer tissues were much higher than those in other solid cancers. ADRM1 gene was significantly induced in colon, lung, breast, and ovary cancers, whereas did not significantly in thyroid, liver, prostate, and kidney cancers. Western blot analysis of the various cancer tissues revealed consistent and preferential expression of ADRM1 in colon and lung cancers. Taken together, the striking and preferential inductions of ADRM1 in colon and lung cancers may enable their use as corresponding cancer markers. *This work was financially supported by Regional Research and Development Cluster Project (B0009735) funded by the Ministry of Knowledge Economy (MKE) of Korea.