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Effects of Procedural Pain on ATP Metabolism and Oxidative Stress in Premature Neonates
Author(s) -
Plank Megan Sue,
Asmerome Yayesh,
Slater Laurel,
Ahmed Mohamed,
Angeles Katherine,
Boskovic Danilo,
Angelea Danilyn
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.lb126
Subject(s) - hypoxanthine , uric acid , oxidative stress , xanthine , malondialdehyde , medicine , purine , neonatal intensive care unit , anesthesia , chemistry , biochemistry , pediatrics , enzyme
Infants in the neonatal intensive care unit routinely undergo painful and invasive procedures. This study examines the effects of procedural pain on ATP metabolism and oxidative stress in two groups of preterm neonates: neonates experiencing a tissue‐damaging procedure (TDP) and those not experiencing any TDP (control group). Procedural pain was measured before and during the TDP using the Premature Infant Pain Profile (PIPP). ATP metabolism and oxidative stress were quantified by measuring levels of hypoxanthine, xanthine, uric acid and malondialdehyde(MDA) in plasma obtained before and thirty minutes after a TDP. We found that pain scores and MDA were higher in neonates undergoing a TDP. Purine breakdown was also found to be significantly enhanced in neonates undergoing a TDP. There were significant correlations between the PIPP pain score and hypoxanthine, xanthine and uric acid. Our data demonstrate that commonly performed NICU procedures increase pain as well as ATP utilization and oxidative stress measured by significant changes in plasma levels of hypoxanthine, uric acid and MDA.