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Skeletal muscle protein synthesis and mTORC1 signaling following resistance exercise in young and older men and women
Author(s) -
Fry Christopher S,
Drummond Micah J,
Glynn Erin L,
Dickinson Jared M,
Gundermann David M,
Timmerman Kyle L,
Dhanani Shaheen,
Volpi Elena,
Rasmussen Blake B
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.997.10
Subject(s) - anabolism , resistance training , medicine , endocrinology , muscle hypertrophy , mtorc1 , p70 s6 kinase 1 , sarcopenia , leg press , skeletal muscle , biology , signal transduction , genetics , pi3k/akt/mtor pathway
Resistance exercise (RE) training causes muscle hypertrophy in young men and women, but the anabolic response is usually greater in men. Following RE training in older individuals, men have larger increases in muscle size and strength. We hypothesized the muscle protein anabolic response to an acute bout of RE would be the greatest in young men. Young (28±2yrs) and older (69±2yrs) men and women performed a bout of RE at 70% of their maximal strength. Muscle biopsies were obtained at baseline, 3, 6 and 24h post‐RE. Muscle protein synthesis (MPS) and mTORC1 signaling were assessed with stable isotopic techniques and immunoblotting. Post‐RE MPS increased similarly in young men and women (P>0.05). Preliminary data show MPS rates are lower, with no sex‐based differences, in older individuals following RE (P>0.05). Phosphorylation of S6K1 (Thr389) increased similarly at 3, 6 and 24h post‐RE in the young (P<0.05) and increased similarly at 3 hr post‐RE in older men and women but the response was not as prolonged as in young. Although there are notable age‐related differences, it appears that there are no sex‐based differences in the acute muscle protein anabolic response following a bout of high‐intensity RE. Supported by NIH R01AR049877, P30AG024832 and T32HD07539.