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Simultaneous introduction of a novel high fat diet and wheel running induces anorexia
Author(s) -
Scarpace Erin,
Matheny Mike,
Cheng KitYan,
Erdos Benedek
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.994.4
Subject(s) - anorexia , endocrinology , medicine , wheel running , food intake , zoology , chemistry , biology
Wheel running (WR) in rodents influences ingestive behavior, and scheduled feeding induces an anorexia that is associated with increased WR. We examined a new phenomena where the simultaneous introduction of both a novel high‐fat (HF) diet plus WR induces a severe anorexia in both young and aged F344 × BN rats. Rats were conditioned to normal chow (67±4 kcal/day) with and without WR. Chow was replaced with 60% HF and half the sedentary rats were switched to WR and half WR rats switched to sedentary. All groups experienced a hyperphagia except the sedentary introduced to HF plus WR which ate less than 10 kcal/day for three days. When HF and WR was introduced simultaneously, with continued availability of chow, rats ate more food (21±4 kcal/day), but less than WR then HF‐fed control (119±4 kcal/day). Similar results were observed in aged rats even though aged (162±23 m/day) ran considerably less than young (1139±185 m/day), suggesting it is the act of WR rather than the extent of WR. These results demonstrate that the act WR plus the novel introduction of a HF diet induces a severe anorexia in young and old rats despite the ad libitum availability of food. Supported by NIH AG‐26159 and P30 AG028740.