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Effects of ganoderma lucidum spores powder on expression of NCAM‐1 and NCAM‐L1 in hippocampus of rats with epilepsy
Author(s) -
Wang ShuQiu,
Kang YuMing,
Qi ZongChun,
Ma XiaoRu,
Liang YanFeng,
Li DianGang,
Zhang Bo
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.993.9
Subject(s) - neural cell adhesion molecule , epilepsy , spore , hippocampus , ganoderma , immunohistochemistry , adhesion , cell , ganoderma lucidum , medicine , chemistry , biology , cell adhesion , biochemistry , neuroscience , immunology , microbiology and biotechnology , traditional medicine , organic chemistry
To investigate the effects of ganoderma lucidum spores powder on expression of neural cell adhesion molecule (NCAM‐1) and NCAM‐L1 of nerve cells in hippocampus of rats with epilepsy emblazed by pentylenetetrazol (PTZ) and study the mechanism of epilepsy and improvement mechanism by ganoderma lucidum spores powder. Thirty male Wister rats were divided into three groups randomly: ganoderma lucidum spores powder, epilepsy model and control groups. The expression of NCAM‐1 and NCAM‐L1 can be detected in each group. The results showed that, compared with control group the NCAM‐1 positive cells and the expression of NCAM‐1 and NCAM‐L1 were increased obviously in epilepsy model group, while the expression of NCAM‐1 and NCAM‐L1 ganoderma spores powder group decreased obviously compared with epilepsy model group. Conclusion Both of NCAM‐1 and NCAM‐L1 play a role in the starting and developing of epilepsy caused by PTZ; Ganoderma lucidum spores powder could inhibit the growth of axons of neurons and transmembrane signal transduction in the nervous system, and reduce cell‐cell adhesion by down‐regulating expression of NCAM‐1 and NCAM‐L1, while synaptic plasticity of the nervous system was reduced and have anti‐epileptic effect. Ganoderma lucidum spores powder is an assistant medicine to cure epilepsy, and it may become a clinical drug to protect brain against epilepsy.