Premium
Influence of oral vitamin C on vasoconstrictor response to local cooling in human skin
Author(s) -
Yamazaki Fumio,
Takahara Kazuo,
Sone Ryoko
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.991.28
Subject(s) - microdialysis , forearm , vasodilation , medicine , vasoconstriction , endocrinology , vasoconstrictor agents , oral administration , blood pressure , vitamin c , chemistry , surgery , central nervous system
Local administration of vitamin C (VC) at a very high physiological concentration (10mM) using intradermal microdialysis technique inhibits the cutaneous vasoconstrictor response to local skin cooling (LC) through adrenoceptor function in humans. But the effect of orally ingesting VC at physiological concentrations on the LC‐induced vasoconstrictor response remains unknown. The purpose of the present study was to test the hypothesis that oral VC enhances the cutaneous vasoconstrictor response to LC by inhibiting the oxidation of norepinephrine. Skin blood flow (SkBF) was measured by laser Doppler flowmetry at three sites (forearm, calf, palm) in healthy volunteers. The three skin sites were locally cooled from 34°C to 24°C at −1°C/min and maintained at 24°C for 20 min before (Pre) and 1.5 h after (Post) oral VC (2g single does) or no VC supplementation (time control study). Cutaneous vascular conductance (CVC) was calculated as the ratio of SkBF to blood pressure and expressed relative to the baseline value before LC. Oral VC enhanced ( P <0.05) the reductions in CVC in the forearm (Pre, −48%; Post, −55%), calf (Pre, −43%; Post, −63%) and palm (Pre, −26%; Post, −54%) during LC. In the time control study, changes in CVC at each site during LC did not differ between the two trials. It was suggested that acute administration of oral VC enhances the vasoconstrictor responses to local cooling in glabrous and nonglabrous skin.