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Liposomal Amikacin (Arikace™) in the Treatment of Lower Respiratory Tract Escherichia Coli in A Patient with Cystic Fibrosis
Author(s) -
Laskoski John,
Landon Chris
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.970.7
Subject(s) - amikacin , sputum , cystic fibrosis , pseudomonas aeruginosa , medicine , antibiotics , respiratory tract infections , microbiology and biotechnology , cephalosporin , escherichia coli , gastroenterology , respiratory system , biology , bacteria , pathology , tuberculosis , biochemistry , genetics , gene
Objective Aerosolized antibiotics are directed against Pseudomonas aeruginosa in cystic fibrosis (CF). E. coli decolonization was attempted in a colonized CF patient with multiple IV and oral drugs, including aminoglycosides, cephalosporins, and carbapenems prior to the use of Arikace™. We hypothesized that novel drug formulation nebulized liposomal Amikacin (Arikace™) will eliminate E‐coli from the lower airways. Methods Four Arikace™ treatment cycles were administered over a 7 month period in three treatment cycles of 28 d, and the fourth of 56 d. A non‐treatment cycle of 28 d was observed between each of the treatment cycles. Results Quantitative analysis of sputum confirmed a reduction in the bacterial load of one strand of E.coli from 2.4 x 10E6 cfu/gram to 1.0–10E3 cfu/gram. The density of a second strand of E. coli increased from16 x 10E6 cfu/gram to 18 x 10E6 cfu/gram post‐treatment. Decreased levels of multiple other pathogens were observed. The patient's sputum mass decreased from a pre‐treatment value of 11.1 g to 4.66 g following treatment. Conclusions Arikace™ is a valuable tool to decrease E. coli infection of the lower airways.