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Effect of Resveratrol and Curcumin on Tumor Volume and Survival in Ehrlich Ascites Carcinoma‐Bearing Mice
Author(s) -
ElAzab Mona Farag,
Hishe Hailemichael,
Moustafa Yasser,
ElAwady ElSayed
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.964.9
Subject(s) - curcumin , carboplatin , ehrlich ascites carcinoma , resveratrol , life span , ascites , pharmacology , carcinoma , chemotherapy , medicine , cancer research , tumor cells , cisplatin , gerontology
Solid tumors were induced by a subcutaneous injection of Ehrlich ascites carcinoma (EAC) cells (2.5x10 6 cells/mouse) in the right flank of Swiss albino mice. These tumors were used to evaluate the antitumor effect of resveratrol (10mg/kg, i.p), or curcumin (10mM, 100μl/mouse, i.p.) as individual treatments or in combination with carboplatin (5mg/kg, i.p). Tumor size was measured every other day for 21 days. Mortality was recorded daily along the study period to calculate the percentage survival of animals, mean survival time (MST) and percentage increased life span (%ILS). Individual treatments with resveratrol or curcumin produced a significant reduction (p≤0.05) in tumor volume, which tended to be enhanced progressively from the individual treatments to the combinations with carboplatin. The treatment with carboplatin, curcumin and their combination could expand the life span of animals for 78, 107 and 105 days respectively. The combination of curcumin with carboplatin could produce the highest increase in MST (68.20±6.70) and %ILS (82.4%). Single and combined treatment of resveratrol produced an enhancement of the life span by 34% and 57.2%, respectively. These data show that resveratrol and curcumin produced antitumor effect on EAC solid tumor in Swiss mice. The results suggest the beneficial role of the phytochemicals as adjuvants to chemotherapy in the treatment and/or prevention of cancer.