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Adenosinergic Modulation Of The Imidazoline I1‐Receptor‐Dependent Hypotensive Effect Of Ethanol In Acute Renal Failure
Author(s) -
ElMas Mahmoud M,
ElGowelli Hanan M.,
Harraz Osama F.,
Ghazal AbdelRheem M.,
Mohy ElDin Mahmoud M.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.961.10
Subject(s) - moxonidine , adenosinergic , chemistry , imidazoline receptor , adenosine receptor , pharmacology , endocrinology , adenosine receptor antagonist , adenosine , medicine , agonist , receptor , ethanol , adenosine a1 receptor , antagonist , biochemistry
We recently reported that ethanol lowers blood pressure (BP) in rats with acute renal failure (ARF) via facilitation of sympathoinhibitory pathways of central imidazoline I 1 ‐receptors. This study investigated whether adenosine receptor subtypes modulate the ethanol‐I 1 ‐receptor interaction. The effect of selective blockade of adenosine A 1 , A 2A , or A 2B receptors on hemodynamic responses to consecutive administration of moxonidine, I 1 ‐receptor agonist, and ethanol was determined in the glycerol model (10 ml/kg, i.m.) of ARF. Ethanol (1 g/kg i.v.) elicited significant decreases and increases in BP and heart rate (HR), respectively, in ARF rats. Prior exposure to moxonidine abolished the hypotensive but not the tachycardic effect of ethanol. The ability of moxonidine to abolish ethanol hypotension disappeared after selective blockade of adenosine A 1 or A 2A receptors with 8‐Cyclopentyl‐1,3‐dipropylxanthine and 8‐(3‐chlorostyryl) caffeine, respectively. In contrast, the moxonidine‐ethanol interaction was not affected in presence of alloxazine, a selective A 2B antagonist or 8‐phenyltheophylline, a nonselective adenosine receptor antagonist. These findings suggest that alterations caused by moxonidine in adenosine A 1 and A 2A receptor signaling function to offset the I 1 ‐receptor‐dependent hypotensive action of ethanol in ARF rats.