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Renin/prorenin receptor decreased expression in heart during pregnancy‐induced hypertension in rats
Author(s) -
LopezSanchez Pedro,
Lopez Emilio Moctezuma,
Avila Massiel Alfonsina,
AnguianoRobledo Liliana
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.955.3
Subject(s) - preeclampsia , renin–angiotensin system , medicine , pregnancy , endocrinology , pathophysiology , proteinuria , blood pressure , receptor , receptor expression , biology , kidney , genetics
Pregnancy courses with low vasopressor response to angiotensin II (Ang II). In preeclampsia or pregnancy‐induced hypertension (PIH), this effect is reverted. Recently, it has been reported a novel receptor in the renin angiotensin system, the Renin/Prorenin receptor (RPR). It is not well described the probable role of this receptor during preeclampsia. The aim of this work was to study if RPR modifies its expression in heart during PIH. We used a subrenal aorctic coarctation (SRAC) model in female Wistar rats, measuring blood pressure, proteinuria and pups weight. Heart was weighted and auricular, septum and ventricular tissue samples were homogenized and immunoblotted using an Anti‐RPR antibody. We found hypertension and proteinuria in SRAC‐pregnant rats and RPR expression in both, pregnant non‐SRAC and pregnant SRAC groups. In pregnant non‐SRAC rats, RPR is abundantly detected. In pregnant SRAC rats however, we found a lower expression of this receptor. These results suggest that RPR is expressed in normal pregnancy and decreased expression during preeclampsia may indicate a role in the pathophysiology of pregnancy‐induced hypertension. Supported by SIP‐IPN 20090153 and 20090396 grants