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Female rats fed low level whole cottonseed for life develop apparent brain neurofibrillary tangles
Author(s) -
Semon Bruce Andrew
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.948.1
Subject(s) - cottonseed , biology , zoology , brain tissue , endocrinology , medicine , anatomy , food science
13 female rats were fed for their lifetimes a 14% soy protein diet as control. 13 rats were fed control diet plus 0.013% whole cottonseed (WCS 0.013%) and 13 rats were fed control diet plus 0.13 % whole cottonseed (WCS 0.13%). Apparent brain neurofibrillary tangles were found in one of three of the longest surviving WCS 0.013% rats and in five of five of the longest surviving WCS 0.013% rats. No neurofibrillary tangles were found in brain of control rats. Lifetime feeding of small amounts of WCS leads to brain findings seen in human Alzheimer's. This study was funded privately by the Wis. Institute of Nutrition,