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Acidic diet and bone mineral content in older men: the CHAMP‐study
Author(s) -
Heer Martina,
Chen Charles,
Cumming Robert G,
Lichfield Melisa,
Naganathan Vasikaran,
Blyth Fiona,
Creasey Helen,
Waite Louise,
Handelsman David J,
Le Couteur David,
Sambrook Philip,
Seibel Markus J
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.946.9
Subject(s) - medicine , osteoporosis , endocrinology , bone resorption , bone mineral , resorption , parathyroid hormone , population , sarcopenia , bone remodeling , calcium , environmental health
Dietary habits may contribute to bone loss in older adults. We studied the effect of dietary potential renal acid load (PRAL) on bone health in a representative sub‐set of older men (n= 920, age 76.5 ± 4.9 (SD) yrs; body weight 80.1 ± 12.8 (SD) kg) of the CHAMP (Cumming et al. 2009) population‐based cohort. Average daily PRAL was calculated from a self‐reported dietary habit questionnaire. Total bone mineral content (BMC) and density (BMD) were analyzed by DXA (Hologic). Fasting morning serum samples were analyzed for intact parathyroid hormone (PTH), procollagen type I aminoterminal propeptide (a bone formation marker) as well as urinary cross‐linked aminoterminal telopeptide (a bone resorption marker). Men with an acidic diet (508, 55%) had significantly lower BMC (adjusted mean: 2488 vs. 2577g; P<0.001) and BMD (adjusted mean: 1.13 vs. 1.16 g/cm 2 ; P=0.01) compared with men having an alkaline diet (412, 45%) after adjustment for confounders (age, body size, smoking, medication affecting bone mass or muscle strength). Additional adjustment for PTH and renal function did not change the results. Bone formation and resorption markers were unrelated to PRAL. We conclude that a predominantly acidic diet is associated with lower bone mineralization, which may increase the risk of osteopaenia and osteoporosis in older men.