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Higher protein weight loss diet does not affect bone mineral density (BMD) in a double‐blind RCT in postmenopausal women
Author(s) -
Thorpe Matthew P,
Mojtahedi Mina C,
Richey Abby L,
Layman Donald K,
Evans Ellen M
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.946.6
Subject(s) - medicine , multivitamin , bone mineral , vitamin , vitamin d and neurology , context (archaeology) , randomized controlled trial , calcium , zoology , endocrinology , osteoporosis , biology , paleontology
In spite of longstanding theory that protein intakes above the RDA are harmful to bone, clinical trials have variably shown no influence or protection of bone with higher protein intakes during weight loss. Studies to date have failed to match intakes of calcium and vitamin D, leaving the independent effect of protein ambiguous. We prescribed a conventional, MyPyramid‐based energy restricted diet (1500 kcal/d) to 31 postmenopausal women (age 65±5y, BMI 33.8±4.9), then randomly assigned 50g/d of supplemental maltodextrin (CARB) or whey protein isolate (PRO) to be added as 25g doses to breakfast and lunch, for 0.8g/kg total protein in CARB and 1.4g/kg in PRO groups. All women received 1g Calcium and 800 IU Vitamin D as a daily multivitamin. After 6 mo, women lost (PRO, CARB) 9.8±6.7, 4.8±3.7% of baseline weight (p=0.06). Bone mineral density changed 2.4, 2.1% (p=0.70) for whole body, −0.8, 1.4% (p=0.13) for lumbar spine and −0.4 and −0.2% (p=0.84) for total hip. This double blind, randomized, controlled trial supports growing consensus that higher protein intakes are not harmful to bone in the context of adequate calcium and vitamin D intakes. Support: National Dairy Council & Carraway Foundation