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Contribution of Inflammatory Markers to Changes in Bone in Postmenopausal Women: A 1‐Year Investigation
Author(s) -
Gertz Erik R,
Silverman Natalie,
Wise Kristine S,
Stewart Jeanne W,
Hanson Kathy B,
Alekel D Lee,
Van Loan Marta D
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.946.13
Subject(s) - medicine , bone mineral , osteoporosis , bone remodeling , quantitative computed tomography , bone resorption , endocrinology , tibia , postmenopausal osteoporosis , postmenopausal women , inflammation , surgery
Bone formation and resorption can be influenced by inflammation as reflected by inflammatory markers. The objectives of our study were to examine the relationships among inflammatory markers and bone mineral content (BMC) and density (BMD) and determine the contribution of inflammatory markers to 1‐year changes in BMC and BMD in healthy postmenopausal women. Data from the Soy Isoflavones to Reduce Bone Loss study (n=235) were examined. BMC and BMD from the lumbar spine & total proximal femur (hip) were measured by dual energy x‐ray absorptiometry and 4% tibia by peripheral quantitative computed tomography. Inflammatory markers (C‐reactive protein (CRP), interleukin (IL)‐1β, IL‐6, TNF‐α) were measured at baseline, 6 & 12 mos. Significant negative associations among inflammatory markers (Il‐6, TNFα) were observed at 6 & 12 mo. for % change in hip, spine, and whole body BMC and BMD. There were no significant associations with inflammatory markers for 4% tibia BMC or BMD. Multiple regression analysis was used to model the contribution of inflammatory markers to %change in BMC and BMD, accounting for ~ 2–7% of the variance. Inflammatory markers made a small but significant contribution to the observed changes in BMC and BMD in healthy postmenopausal women. Research was supported by NIH‐NIAMS (RO1 AR046922), USDA/ARS, WHNRC, NWRC, ISU; CTSC, CCRC, UCD (1M01RR19975‐01), National Center for Medical Research (UL1 RR024146).