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Prediction of biological docosahexanoic status using novel and traditional dietary assessment tools
Author(s) -
Filipowicz Rebecca,
Foster Randal,
Campbell Christina
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.939.16
Subject(s) - medicine , food frequency questionnaire , zoology , biology
Maternal intake of docosahexanoic acid (DHA) is associated with fetal neurodevelopment. Limited data exists to identify the appropriate dietary assessment tool for DHA. We aim to determine the relationship between DHA intake and status in non‐coastal pregnant women. Dietary data were collected using a food frequency questionnaire (FFQ) and a weighed 3 day diet record (3dDR) (week 28 of gestation). Maternal blood was analyzed for DHA in plasma phospholipids (PL), red blood cell phosphatidylethanolamine (PE)(adjusted for plasmalogen) and phosphatidylcholine (PC). Fits were analyzed using Pearson correlation coefficients (SAS, Cary, NC). Level of significance was P<0.05. Overall (n=31) DHA intake for the FFQ and blood fractions were significant (PL: R=0.565, P<0.001; PC: R=0.697, P<0.0001, PE: R=0.391, P<0.05) compared to 3dDR results (PL: R=0.524, P<0.005, PC: R=0.618, P<0.001, PE: R=0.064, NS). Data were separated into two groups: 1) >200 mg DHA/d for FFQ and 3dDR (n=12) or 2) <200 mg DHA/d on 1 or both measures (n=19). For Group 1, the FFQ correlated with PL (R=0.583, P<0.05) and PC (R=0.599, P<0.05) but not PE. For Group 2, the FFQ and PC (R=0.463, P<0.05) were significantly correlated. The FFQ is the preferred assessment tool because it more accurately reflects biological status and can better quantify lower DHA intake. Grant Funding Source : P20 RR‐16455‐07 from the NCRR, a component of the NIH.