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The expression of tetranectin is affected by polyunsaturated fatty acids in human adipocytes
Author(s) -
Wang YaChing,
Wu HsinTing,
Lin HsinYu,
Ding ShihTong
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.939.10
Subject(s) - adipogenesis , adipocyte , polyunsaturated fatty acid , docosahexaenoic acid , eicosapentaenoic acid , lipolysis , lipid metabolism , chemistry , medicine , messenger rna , endocrinology , fatty acid , biology , biochemistry , adipose tissue , gene
Tetranectin (TN) enhances fibrolysis specifically by binding to the plasminogen‐like hepatocyte growth factor and tissue‐type plasminogen activator (tPA). Tetranecttin is an inducer of plasminogen activation which is catalyzed by tPA. We detected the expression of TN in human adipocytes. Using the primers of TN exon1 to detect TN mRNA expression by real‐time PCR, we found that TN mRNA expression was positive correlated with both adipogenesis and human body mass index (BMI). Many genes involve in lipid metabolism is regulated by polyunsaturated fatty acids (PUFA) in adipocytes. PUFA also regulate the adipocyte differentiation, adipogenesis, and lipolysis. We treated human adipocytes with different PUFA, include docosahexaenoic acid, eicosapentaenoic acid, and arachinonic acid and found that PUFA decreased the expression of TN mRNA expression. These results suggest that TN may have a role related to regulating lipid metabolism in adipocytes. The project was funded in part by the National Science Council in Taiwan. Grant Funding Source : The project was funded in part by the National Science Council in Taiwan