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Low density lipoprotein quantification: a new look
Author(s) -
SchleglZawadzka Malgorzata,
Hartwich Jadwiga
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.938.9
Subject(s) - ldl cholesterol , lipoprotein , subclass , cholesterol , low density lipoprotein , myocardial infarction , medicine , endocrinology , plasma lipoprotein , chemistry , antibody , immunology
Routine lab test for quantification of LDL plasma level is regarded as LDL cholesterol assessment. LDL is not a homogenous entity. The relative content of cholesterol decreased from large more buoyant to small, dense (sdLDL) particles (Swinkels 1987). LDL phenotype B i.e. the predominance of sdLDL in LDL plasma pool was significantly associated with a threefold increased risk of myocardial infarction (Austin 1988). People with low or normal cholesterol may have a high number of LDL particles, even if their cholesterol is being lowered by diet, exercise, or medication (Cromwell 2006). The need of therapeutical modulation of small, dense LDL particles content in LDL plasma pool is widely discussed (Rizzo 2007). Dietary effects differ in subject with LDL subclass phenotypes A and B (Krauss 2005). Diet‐induced favorable changes in plasma lipid and lipoprotein profile were noted only in the ‘post‐dietary LDL density responders’ (Hartwich 2009). Qualitative and quantitative measurements of LDL have been shown to be of benefit in cardiovascular risk assessment, so the classic lipoprotein analysis should be improved by high separation techniques.