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Erythrocytes fatty acid composition and dietary intakes are correlated with markers of atherosclerosis in patients with myocardial infarction
Author(s) -
Park Yongsoon
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.937.1
Subject(s) - niacin , medicine , vitamin , linoleic acid , food science , fatty acid , oleic acid , vitamin e , chemistry , endocrinology , biochemistry , antioxidant
The purpose of this study was to examine the hypothesis that erythrocytes that are lower in n‐3 fatty acids and higher in trans fatty acids, and nutrient intakes were associated with the risk of atherosclerosis. Fifty patients with acute nonfatal myocardial infarction were recruited in order to measure their dietary intake, erythrocyte fatty acid composition, intima medial thickness (IMT) and the Gensini score, which are markers of atherosclerosis. Trans oleic acid of erythrocytes was positively (P = 0.05) correlated with the carotid IMT. After adjusting for age, sex, and energy intake, the IMT was negatively associated with the intake of protein, fat, phosphate, zinc, vitamin B1, vitamin B2, vitamin B6, niacin, linoleic acid, linolenic acid, total fatty acids, total n‐3 fatty acids, and total n‐6 fatty acids. The Gensini score was also negatively associated with the intake of protein, fat, phosphate, sodium, zinc, vitamin E, vitamin B1, vitamin B2, vitamin B6, niacin, linolenic acid, total fatty acids, and total n‐3 fatty acids. In conclusion, lower levels of trans oleic acid in erythrocytes and higher intakes of vitamins, minerals, and n‐3 fatty acids were associated with the decreased risk of atherosclerosis. This work was supported by the Korean Research Foundation Grant that is funded by the Korean Government (MOEHD, Basic Research Promotion Fund, KRF‐2007‐331‐C00279).