Premium
Hormonal and body composition changes associated with amelioration of diet‐induced obesity by deoxynivalenol in the mouse
Author(s) -
Hattori Kazuo,
Flannery Brenna,
Amuzie Chidoze,
Pestka James
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.936.7
Subject(s) - endocrinology , medicine , leptin , obesity , lean body mass , hormone , insulin , chemistry , diet induced obese , body weight , fat mass , weight gain , insulin resistance
Consumption of the mycotoxin deoxynivalenol (DON) ameliorates weight gain in diet‐induced obese (DIO) mice. DON's therapeutic effects in DIO mice were related to food intake, body fat mass, lean weight and selected obesity‐related plasma hormones. Female B6C3F1 mice were fed 10% kcal control (CON) diet or 45 and 60% kcal high fat diets (HFD). After obesity induction (94 d), half of each high fat group was continued on same diet and the other half fed HFD containing 10 ppm DON from day 94 to 148. HFD‐DON‐fed mouse body weights decreased rapidly to that of CON by day 105 and maintained at that level thereafter. Food intake by the HFD‐DON‐fed groups significantly decreased as compared to HFD from day 98 and 101 concurrently with robust decreases in body weight. MRI data revealed that fat mass and body fat percentages of the HFD‐DON‐fed mice rapidly decreased to those of CON while reduced lean weights were detectable day 122. HFD‐DON‐fed mice had decreased plasma levels of insulin‐like growth factor 1 (IGF‐1) compared to HFD. HFD‐fed mice exhibited increases in plasma insulin and leptin which were suppressed in HFD‐DON‐fed mice. Accordingly, DON‐induced body weight reduction in DIO mice is accompanied by decreased body fat mass and lean weight. These effects correspond to both decreased food intake and marked reductions in plasma IGF‐1, insulin and leptin. Supported by USDA Agreement No. 59‐0790‐4‐119/PHS Grant ES03358.