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Relationship between elevated serum alanine aminotransferase concentration and metabolic syndrome in Korean adults
Author(s) -
Kim Jihye
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.935.6
Subject(s) - medicine , metabolic syndrome , odds ratio , body mass index , abdominal obesity , national health and nutrition examination survey , national cholesterol education program , triglyceride , nonalcoholic fatty liver disease , alanine aminotransferase , obesity , endocrinology , alanine transaminase , fatty liver , gastroenterology , population , cholesterol , disease , environmental health
The elevation of alanine aminotransferase (ALT) have been strongly associated with adiposity and may represent nonalcoholic fatty liver disease. We investigated the relationship between metabolic syndrome and elevated ALT in the general Korean population. The study sample was comprised of 4,781 Korean adults who had participated in the 2005 Korean National Health and Nutrition Examination Survey. Metabolic syndrome was defined by National Cholesterol Education Program for Adult Treatment Panel III. Elevated ALT was defined as an enzyme activity >40 IU/L for men, and >31 for women. Among participants, 425 (8.9%) subjects displayed elevated ALT. The odds ratios (95% CIs) for elevated ALT were 3.5 (2.8–4.8), 2.2 (1.7–2.7), 2.4 (1.9–3.1), 3.8 (3.1–4.7), and 1.8 (1.5–2.2) in subjects with abdominal obesity, high blood pressure, high fasting glucose, high triglyceride, and low HDL cholesterol after adjusting for age and sex. The odds ratios for elevated ALT were 1.3 (0.96–2.32) 3.0 (1.98–4.61), and 6.3 (4.29–9.35) (P for trend<0.0001) in Korean adults with 1, 2, and ≥3 risk factors when adjusted for age, sex, body mass index, smoking status, alcohol intake. Metabolic syndrome was strongly associated with elevated ALT concentration in Korean adults.