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Body fat correlates with metabolic and inflammatory markers in clinically healthy obese Mexican subjects
Author(s) -
KauferHorwitz Martha,
ValenciaBarragán Karla Ivet,
Saldaña Reyna,
Gómez Francisco Enrique
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.935.4
Subject(s) - adiponectin , medicine , leptin , waist , endocrinology , insulin , obesity , insulin resistance , metabolic syndrome
Background Obesity is characterized by metabolic alterations and low‐grade systemic inflammation. Our aim was to describe the correlation of % body fat (%BF) with metabolic and inflammatory markers in clinically healthy obese (HO) and non‐obese (HN) subjects. Methods We studied 18 (10 ♀ and 8 ♂) HO Mexican patients of the Obesity Clinic, age 31±5y, BMI 40.1±2.4, and 46 (39 ♀ and 7 ♂) HN subjects age 25±5y, BMI 21.5±1. They had no associated morbidity, evidence of infection, were not taking anti‐inflammatory drugs, were not pregnant or lactating & gave informed consent. Weight, height and waist circumference (WC) were assessed in triplicate by standard methods. %BF was assessed by bioimpedance. Fasting serum levels of glucose, insulin, leptin, adiponectin, TNF‐α and IL‐6 were assessed by standard methods. Student‐T test and Pearson coefficient were calculated. Results Subjects in HO were normoglycemic (83.4±9.8mg/dL) and hyperinsulinemic (1165±600pg/mL), with HOMA=5.82±3.4; compared to HN (glucose=78.2±7.2; insulin=392±161; HOMA=1.84±0.83); p≤0.02. Lower levels of adiponectin and higher levels of leptin, TNF‐α, IL‐6 were found in HO (p≤0.02). Positive and significant correlations were found between %BF and insulin (r=.78♀, r=.69♂), and HOMA (r=.75♀, r=.70♂), but not with glucose. Although %BF correlated with WC in men and women (r=.94, .97; p<.0001), it correlated with TNF‐alpha (r=.35) and IL‐6 (r=.44) only in women. Conclusion %BF was associated with an inflammatory profile and hyperinsulinemia in normoglycemic “healthy” obese subjects. Men seem to be more protected than women in terms of the effect of %BF on inflammation. (Partially supported by CONACYT, México)