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Metabolic syndrome in healthy, multiethnic adolescents in Toronto: the use of fasting blood glucose as a simple indicator
Author(s) -
Vuksan Vladimir,
Rogovik Alexander,
Peeva Valentina,
BeljanZdravkovic Uljana,
Stavro Mark,
Jenkins Alexandra,
Dias Andre,
Devanesen Sudi,
Fairgrieve Christopher,
Hanna Amir
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.933.2
Subject(s) - medicine , waist , metabolic syndrome , blood pressure , post hoc analysis , stepwise regression , analysis of covariance , circumference , linear regression , obesity , statistics , mathematics , geometry
Objectives To assess the presence of metabolic syndrome (MetS) features in healthy, normal‐weight, multiethnic adolescents and to determine whether fasting blood glucose (FBG) may be a simple indicator of its presence. Methods A cross‐sectional study using a convenience sample of secondary school students. GLM ANCOVA adjusted for multiple pairwise comparisons by the post hoc Tukey‐Kramer test was used to assess differences among the tertiles of FBG. Results A total of 182 adolescents from 62 Greater Toronto Area (GTA) secondary schools were recruited (44% Caucasian, 34% South Asian, and 22% Chinese), with mean(SD age 17.4±0.9 years, BMI 22.1±3.4 kg/m2, and FBG 4.92±0.4 mmol/L. Analysis with GLM ANCOVA across the tertiles of FBG (3.83–4.78 mmol/L, 4.79–5.08 mmol/L, and 5.09–6.45 mmol/L) showed significant linear increases of BMI (p<0.005), waist circumference (p<0.001), systolic blood pressure (p<0.001), and diastolic blood pressure (p<0.05) with increasing FBG. Stepwise multiple regression analysis indicated systolic blood pressure and waist circumference as independent predictors of the increased FBG level. Conclusions MetS markers are present in a sample of healthy multiethnic adolescents in GTA. FBG could be used as a simple indicator of MetS to allow for early detection of MetS presence and introduction of preventive lifestyle measures.