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Use of HbA 1c in Screening for Cuban‐Americans with Undiagnosed Type 2 Diabetes
Author(s) -
Exebio Joel C.,
Zarini Gustavo G.,
Exebio Cristobal,
Huffman Fatma G.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.932.8
Subject(s) - medicine , diabetes mellitus , national health and nutrition examination survey , type 2 diabetes , plasma glucose , receiver operating characteristic , gastroenterology , endocrinology , population , environmental health
The study evaluated the use of HbA 1c as a screening tool for undiagnosed type 2 diabetes (fasting plasma glucose > 7.0 mmol/l) in a sample of Cuban‐Americans. Subjects were randomly recruited from Miami‐Dade and Broward counties, FL. Fasting plasma glucose (FPG) was measured by hexokinase enzymatic method. HbA 1c was measured by the DCA2000+ system using the monoclonal antibody method. HbA 1c demonstrated a high predictive value in detecting undiagnosed diabetes. The area under the receiver operating characteristics (ROC) curve was 0.87. Additionally, HbA 1c had high sensitivity and specificity when using a cut off value of 6.37(%) (71% and 86% respectively). Moderate sensitivity and very high specificity were shown with a cut off value of 6.84 (57% and 96% respectively). In addition, the mean HbA 1c for subjects with normal FPG (<6.1) was 5.9 ± 0.47 which is higher than the mean HbA 1c reported in The National Health and Nutrition Examination Survey (NHANES) for other ethnic groups. HbA 1c is a reliable alternative to FPG in screening for undiagnosed diabetes in Cuban‐Americans. An HbA 1c cut off value of 6.37 shows high sensitivity and specificity for detecting subjects with undiagnosed diabetes in Cuban‐Americans. Supported by a grant from NIH/SCORE.