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A legume enriched diet facilitates weight loss and improves biomarkers of insulin resistance and inflammation
Author(s) -
Zhang Zhiying,
Lanza Elaine,
Mitchell Diane,
MentorMarcel Roycelynn,
Colburn Nancy,
Hartman Terryl
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.931.4
Subject(s) - weight loss , insulin resistance , medicine , legume , endocrinology , glycemic index , vitamin d and neurology , insulin , glycemic , vitamin , glycemic load , obesity , zoology , biology , botany
The LIFE Study tested the effects of a legume enriched, low‐glycemic index, weight maintenance diet on biomarkers of insulin resistance and inflammation among males at high risk for colorectal cancer (n=64). The study included an optional 4‐wk period (n=44) where men continued on the diet with consistent legume consumption but dietary guidance was provided and weight loss encouraged. Mean body weight and BMI significantly decreased by 4.4% (−4.0±0.4 S.E.M. kg) and 1.3 (±0.1 kg/m 2 ), respectively. Levels of serum total cholesterol (TC), LDL‐C, TG, C‐peptide, and fasting plasma glucose, insulin, and C‐reactive protein were all significantly reduced. Compared to the weight maintenance diet, the weight loss diet was lower energy (−770.3 ± 397.0 S.D. kcal/d) and energy density (0.70 vs 1.15, P<0.001). Subjects consumed less total fat (31 vs 34% energy, P<0.001), saturated fat (10 vs 12%, P=0.007), and cholesterol (62.3 vs 70 mg/1000 kcal/d, P=0.0255). After energy adjustment they ate more vegetables (2.6 vs 2.2 serv./1000 kcal/d, P=0.0133) and legumes (1.9 vs 1.5 serv./1000 kcal/d, P=0.0009) during the weight loss phase, and consumed more total carotenoids (10759 vs 8799 μg/1000 kcal/d, P=0.0014), vitamin C (74.0 vs 61.8 mg/1000 kcal/d, P=0.0202), and folate (559.7 vs 444.1μg/1000 kcal/d, P<0.001). These results indicated that a high legume diet may facilitate weight loss and improve the aforementioned biomarkers. Grant Funding Source : National Institute of Health