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Effects of fermented soy food containing natural S‐equol on tail skin temperature in ovariectomized rat.
Author(s) -
Yoneda Takeshi,
Ueno Tomomi,
Iwashita Soh,
Uchiyama Shigeto
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.922.4
Subject(s) - ovariectomized rat , medicine , equol , endocrinology , estrogen , osteoporosis , phytoestrogens , menopause , daidzein , genistein
Equol has been reported to have greater estrogenic activity, decreasing risks of osteoporosis, menopausal symptoms and hyperlipidemia in menopausal women. We succeeded in industrial production of a fermented soy food containing natural S‐equol (FSE) using equol‐producing lactic acid bacteria, Lactococcus 20–92. It was reported that ovariectomized (OVX) rat increase tail skin temperature (TST) like hot flashes in postmenopausal women. We examined the effects of FSE on TST in OVX rat, and compared with Premarin (conjugated estrogen drug). The study groups were consisted of sham, control, Premarin and FSE groups. Sham and control groups were administered vehicle, Premarin group were administered Premarin 6 mg/kg BW and FSE group were administered FSE as equol 12 mg/kg BW for 4 weeks. TST was evaluated at 3rd and 4th week after OVX operation. Uterine weight was measured at 4th week. TST was significantly higher in control group compared with sham group, and significantly lower in Premarin and FSE groups compared with control group at 3rd and 4th week. Premarin group significantly increased the uterine weight reduced after OVX operation, but FSE group did not. These results suggest that FSE is capable to improve hot flashes without effect on reproductive organs in postmenopausal women. Therefore, natural S‐equol might be expected to have activity as a selective estrogen receptor modulators.