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Effects of Ecklonia cava on plasma and liver lipids, platelet aggregation and RBC membrane stability in rats fed cholesterol diets
Author(s) -
Yeh Wan Ting,
Jeon YouJin,
Kang YoungHee,
Kang Jung Sook
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.921.5
Subject(s) - tbars , chemistry , food science , cholesterol , lipid peroxidation , antioxidant , biochemistry
We compared bioactivity of 10% Ecklonia cava (EC) powder, 5% extract (carbohydrase hydrolyzed product) and 3% Dieckol (EC polyphenol) in aspect of antiobese, hypolipidemic, antiplatelet and antioxidant on RBC membrane and TBARS production in rats fed cholesterol diets. The final weight with low food efficiency ratio in rats fed Dieckol was significantly decreased compared with the control (p<0.05). Plasma total cholesterol was significantly decreased in EC powder (p<0.05) and HDL‐cholesterol was significantly decreased in Dieckol (p<0.05) both compared with the control. Liver total cholesterol significantly decreased in EC powder compared with EC extract (p<0.05) and liver TG was significantly decreased in Dieckol compared with control (p<0.05). Platelet agregation both in initial slope and the maximum was significantly decreased in Dieckol compared with the control (both, p<0.05). Erythrocyte Na leak increase after AAPH treatment was significantly high in EC extract compared with other groups (p<0.05), while PRP TBARS porduction was significantly decreased in Dieckol compared with the control (p<0.05). GOT compared with the control and GPT compared with Diekol were significantly decreased in rats fed EC powder (p<0.05). In conclusion, polyphenol rich Dieckol from Ecklonia cava seems to have some favorable effects in weight gain, platelet aggregation, RBC membrane stability and lipid peroxidation, but it is not clear how it acts at this point.