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Effect on Anti‐Diabetic Effect of the Mushrooms Grown in Germinated Brown Rice Extracts in Rin and 3T3‐L1 cells
Author(s) -
Cha YounSoo,
Park JeongEun,
Kang HyunJu,
Soh JuRyoun,
Beak SungHyun
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.920.3
Subject(s) - triglyceride , insulin , chemistry , in vivo , brown rice , secretion , endocrinology , medicine , food science , biology , biochemistry , cholesterol , microbiology and biotechnology
This study investigated the anti‐diabetic activity of functional mushrooms grown in germinated brown rice (FMBL). FMBL extracts were obtained by using methanol extraction and concentration processes. First, insulin secretion‐stimulatory activity of FMBL was examined using the RIN cell line. Insulin and glucose secretion was enhanced in the FMBL extract treatment groups as compared to the non‐treated cells. In addition, the anti‐diabetic effects of FMBL extracts were confirmed by its effects on insulin levels, triglyceride content and PPAR‐γ mRNA expression, and insulin sensitivity in 3T3‐L1 cells. FMBL extract also reduced the PPAR‐γ mRNA expression and triglyceride accumulation in a dose dependent manner as compared to the control. The present study suggests that FMBL deserves to be evaluated for in vivo anti‐diabetic activity in animal and human studies.