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Combination of fenugreek and cayenne improves glucose handling of a type 2 diabetic mouse model
Author(s) -
Hanlon Paul,
Eshelman Bruce,
Harriman William,
Barnes David
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.920.1
Subject(s) - food science , diabetes mellitus , medicine , biology , endocrinology
Fenugreek and cayenne contain bioactive phytochemicals that have both been shown to affect glucose handling. The purpose of this study was to determine the effect of these two foods on glucose handling in a model of diabetes, as well as whether there would be a synergistic effect of these two foods combined. C57BL/KsJ‐ db/db (leptin receptor deficient) diabetic mice were fed a control diet or experimental diets containing 1% ground fenugreek seed, 1% dried cayenne pepper powder or the combination of 1% fenugreek and 1% cayenne for two weeks. Inclusion of fenugreek and/or cayenne did not significantly reduce food consumption, nor did it affect the body weight of the animals. At the end of two weeks, glucose handling was measured by i.p. glucose tolerance test (IPGTT). Mice fed either the fenugreek or cayenne alone diets did not have significant improvement in IPGTT in comparison with control. However, the mice fed the combination of fenugreek and cayenne demonstrated significantly improved glucose handling (115% of baseline after 120 minutes) over control (blood glucose 167% of baseline after 120 minutes). Values for circulating adipokines and hemoglobin A1c are also reported.