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Effect of Magnesium on Heart Rate Variability in Healthy Subjects
Author(s) -
Brilla Lorrie,
Teichler Liza,
Hahn Teresa,
Freeman Jeanne,
Li Ying
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.917.3
Subject(s) - magnesium , medicine , placebo , heart rate variability , chemistry , heart rate , endocrinology , zoology , blood pressure , biology , alternative medicine , organic chemistry , pathology
Magnesium may decrease the concentration of plasma cortisol and catecholamines, hence stress. Healthy, active individuals (N=36) supplemented double‐blind for 6 weeks with 500 mg of Mg in one of two forms (magnesium bisglycinate chelate [MgC] or magnesium oxide [MgO]) or a placebo [P]. All data was collected pre post intervention: 3‐day diet and physical activity records and heart rate variability [HRV]. The subject characteristics were 22.9±4.2 years, 171.7 ±18.8 cm, 71.2± 12.1 kg. There were no significant differences (P>.05) within or between groups in diet. The physical activity levels were significantly different between P and MgO groups, both pre and post (P<.05). There were no within groups difference. Plasma Mg was higher in MgC (P<.05), pre‐post, with a trend for enhanced Mg levels in MgO (P=.12). HRV raw data were transformed to a spectral analysis, with a significant LF/HF interaction effect noted (P<.05). Both Mg groups decreased LF/HF from pre to post, but only MgO had a significant decline (P<.05). The MgO had significant main effects pre to post in LF nu, HF nu, and the LF/HF (P<0.05). Post test differences were observed between P and MgC for LF nu, HF nu, and LF/HF (P<.05). P and MgO differed in post test LF/HF (P<.05). The overall impression is enhanced vagal and diminished sympathetic profiles in both Mg groups, with the reverse demonstrated in P.