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Markers of Bone Turnover, Osteoprotegerin (OPG), and Vitamin D across Gestation in Pregnant Adolescents
Author(s) -
Essley Bridget V.,
McNanley Thomas,
Cooper Elizabeth,
McIntyre Allison,
Kent Tera,
Foehr Marisa,
Witter Frank,
Harris Leah,
O'Brien Kimberly
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.917.11
Subject(s) - osteoprotegerin , medicine , vitamin d and neurology , endocrinology , gestation , bone remodeling , n terminal telopeptide , bone resorption , rankl , pregnancy , gestational age , cord blood , osteocalcin , chemistry , biology , receptor , alkaline phosphatase , biochemistry , activator (genetics) , genetics , enzyme
Pregnant adolescents may be at risk for vitamin D deficiency and bone loss across pregnancy. OPG is a soluble decoy receptor for RANKL, suppressing osteoclast differentiation and activity. To assess relationships between vitamin D, OPG and bone turnover, 25(OH)D, osteocalcin (OC; a marker of bone deposition), N‐telopeptide (NTX; a marker for bone resorption), and OPG were monitored in 88 pregnant adolescents (12–18 yrs) and their neonates. Blood samples were collected at mid‐gestation and at parturition when cord blood and placental tissue were also obtained. In these teens, OC (n=67), NTX (n=98), and OPG (n=66) were significantly elevated at delivery (p< 0.001). The gestational increase in OPG in these teens was larger than has been reported in mature women (p<0.001). Levels of NTX and OC were highly correlated (p<0.01) at mid‐gestation (n=87) and at delivery (n=75). At delivery, OC and NTX were significantly higher in neonatal than maternal circulation (p<0.001, n=69, n=84) while OPG was lower in cord versus maternal blood (p<0.001, n=67). Maternal vitamin D status was inversely related to OC at mid‐gestation (p<0.01, n=89) and at delivery (p=0.05, n=70). OPG was inversely related to vitamin D (p=0.01, n=69) in the neonate at birth. Recruitment and analyses are on‐going. Additional relationships between OPG, vitamin D status, and maternal bone loss and fetal bone accrual will be explored. Grant Funding Source : USDA: 2005‐35200