Premium
Selenium (Se) supplementation for 6 months increases plasma selenium levels in HIV+ adults in Botswana
Author(s) -
Sales Sabrina,
Tsalaile Lesedi,
Burns Patricia J,
Campa Adriana,
Makhema Joseph,
Marlink Richard,
Baum Marianna K
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.916.10
Subject(s) - micronutrient , medicine , asymptomatic , selenium , placebo , viral load , human immunodeficiency virus (hiv) , gastroenterology , nutritional supplementation , cohort , zoology , immunology , biology , chemistry , organic chemistry , alternative medicine , pathology
Objective To determine whether supplementing 200 mg/day of selenium (Se) for 6 months increases plasma Se in asymptomatic, ART naïve HIV+ adults in Botswana. Methods After consenting, 79 participants were randomized into the Se supplementation (N=33) or placebo (N=46). Fasting blood was drawn for plasma Se levels, CD4 cell count and HIV viral load. Se deficiency was defined as <0.085 mg/L. Results Mean age was 34.13±8.0 years and 72.2% were male. The prevalence of Se deficiency in this cohort was 94.9% (n=75). At baseline, there were no significant differences in mean Se levels between the two groups (0.065±0.010 mg/L vs. 0.070±0.024 mg/L, p=0.182). After 6 months of supplementation, there were significant differences in mean Se levels between the Se‐supplemented (0.147±0.153 mg/L) and not supplemented groups (0.069±0.121 mg/L, p<0.001). There were no significant differences in CD4 cell count and viral load between the groups at 6 months. Conclusions Supplementation with Se for 6 months normalized plasma Se in those who were deficient, and increased Se levels in all supplemented participants. This study also demonstrates that Se may be used as an index of adherence in micronutrient supplementation studies that contain Se. Further research is needed to determine the length of supplementation needed at this dose to reach steady state and observe clinical benefits of supplementation. Funded by NIDA