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Pregnant Diabetic Mice have Aberrant Blood Pressure Control and Renal Dysfunction Associated with Fetal Growth Restriction and Death
Author(s) -
Burke Suzanne Diana,
Barrette Valerie F,
Adams Michael A,
Croy B Anne
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.812.8
Subject(s) - medicine , pregnancy , blood pressure , diabetes mellitus , gestation , endocrinology , fetus , type 1 diabetes , hemodynamics , physiology , biology , genetics
Cardiovascular adaptations of pregnancy involve structural and functional changes in the heart and kidneys. Pregnant women with Type 1 Diabetes (T1D) are at high‐risk for developing pregnancy complications. Using radiotelemetry, we sought to investigate the blood pressure regulation of the pregnant T1D non‐obese diabetic (NOD) mouse. Diabetic NOD mice had a normal drop in blood pressure from gestation day 5–9, but became hypotensive and severely bradycardic during late gestation in comparison to pregnant, normoglycemic NOD mice. These acute hemodynamic changes were accompanied by biochemical and histopathological signs renal failure. Pups born to diabetic dams were growth‐restricted, suggesting placental insufficiency. The paradox of rapid onset renal dysfunction, combined with unexpected hypotension and bradycardia suggests that, in diabetes, pregnancy‐induced renal adaptations accelerate renal disease progression, compromising maternal and fetal circulatory health. Funded by CIHR, Canadian Foundation for Women's Health and the Canada Research Chairs Program Grant Funding Source: CIHR