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Understanding zebrafish habituation responses to novelty
Author(s) -
Bartels Brett,
Tien David,
Wong Keith,
Tan Julia,
Cachat Jonathan,
Suciu Chris,
Goodspeed Jason,
Roy Sudipta,
Elegante Marco,
Elkhayat Salem,
Grimes Chelsea,
Rosenberg Michael,
Jackson Andrew,
Chung Amanda,
Gaikwad Siddharth,
Duncan Ashley,
Kadri Ferdous,
Stewart Adam,
Chung Kyung Min,
Strong Michael,
Gilder Thomas,
Zapolsky Ivan,
Kalueff Allan V
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.811.8
Subject(s) - habituation , zebrafish , danio , neuroscience , novelty , anxiogenic , psychology , licking , medicine , pharmacology , anxiety , anxiolytic , biology , psychiatry , social psychology , gene , biochemistry
Though widely used to characterize animal cognitive phenotypes and their modulation, habituation phenotypes have not been extensively investigated in zebrafish (Danio rerio). Utilizing the novel tank test, we examined intra‐ and intersession habituation and demonstrated robust habituation responses in zebrafish. Intrasession habituation analysis determined that selected anxiogenic drugs (caffeine, pentylenetetrazol), as well as stress‐inducing alarm pheromone, attenuated habituation, while the acute anxiolytic agents, morphine and ethanol, had no effect on it. Chronic ethanol and chronic fluoxetine treatment attenuated intrasession habituation in zebrafish. Our study parallels rodent literature on habituation responses to novelty and reconfirms zebrafish as a promising model for cognitive neurobehavioral research. The study was supported by NARSAD, TUNF, TSEF, and TUIRF.