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Reversible inactivation of the medial prefrontal cortex causes antidepressant‐like effects of in rats
Author(s) -
Scopinho América Augusto,
Scopinho Michele,
Aguiar Corrêa Fernando Morgan,
Guimarães Francisco Silveira,
Joca Sâmia Regiane Lourenço
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.811.5
Subject(s) - behavioural despair test , microinjections , prefrontal cortex , antidepressant , infralimbic cortex , anxiolytic , elevated plus maze , chemistry , medicine , endocrinology , tail suspension test , neuroscience , psychology , anesthesia , pharmacology , microinjection , anxiety , psychiatry , receptor , hippocampus , cognition
Reversible inactivation of the prelimbic (PL) and infralimbic (IL) parts of the mPFC with cobalt (CoCl2, a synaptic blocker) produced anxiolytic‐like effects. The aim of the present study was to verify if the same treatment would also induce antidepressant‐like effects in the forced swimming test (FST). Male Wistar rats were stereotaxically implanted cannulae in the PL or IL were submitted to the FST consisting of an initial 15 min swimming session (pre‐test) followed, 24 h later, by the 5 min test session. The animals (n=5–7) received bilateral microinjections of vehicle (200 nL) or CoCl2 (1 mM) into the PL or IL at different periods of the experimental procedure. In the PL CoCl2 induced a decrease in IT that was independent of the moment of the injection (before pre‐test, V: 187.3±25.8 s, CoCl2:157.7±16.2 s, after pre‐test, V: 207.1±6.3 s, CoCl2: 129.6±19.2 s, before test, V: 188.4±20.4 s, CoCl2: 88.1±29.7 s). In the IL, the treatment was effective when administered immediately before pre‐test or before test (before pre‐test, V: 186±21.1 s, CoCl2: 123±4.7 s; before test, V: 186.8±7.8 s, CoCl2: 8.5±2.6 s) but not after the pre‐test (V:161±9.6 s, CoCl2: 178.8±27.1 s). These results suggest that mPFC synaptic activity produces antidepressant‐like effects in this test. Also indicate that, although both the PL and IL cortices seem to be involved in these effects, they may play different roles. Financial support: CAPES, CNPq.