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BPP‐10c from Bothrops jararaca venom changes behavioral and cardiovascular responses to acute stress exposure
Author(s) -
Ianzer Danielle Alves,
Bernardes Isabella,
Lima Augusto M,
Santos Robson A S,
Xavier Carlos H,
Fontes Marco A P
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.811.4
Subject(s) - acute exposure , bradykinin , bothrops jararaca , medicine , venom , endocrinology , anesthesia , pharmacology , chemistry , snake venom , biochemistry , receptor
Bradykinin‐potentiating peptides (BPPs) from Bothrops jararaca venom display strong antihypertensive and bradycardic effects in spontaneously hypertensive rats (SHR). We assessed the contribution of BPP‐10c to locomotor/exploratory activity and cardiovascular reactivity to acute stress exposure. BPP‐10c (71 nmol/Kg) or vehicle (NaCl 0.9%) were i.v. injected in male SHR prior to evaluation of locomotor activity. The behavior was recorded during 210min. Another group was submitted to air jet stress (10L/min‐10 min) at 120min following injections of BPP‐10c or vehicle. Renal sympathetic activity was also measured in anesthetized SHRs. The entire exploratory episodes sampled after BPP‐10c administration were significantly reduced, when compared to vehicle (running: 54±9 vs. 93±12; rearing: 38±7 vs. 79±11; grooming: 2.7±0.4 vs. 5.8±1.4; P<0.05). Despite absence of effects on cardiovascular reactivity to stress, BPP‐10c greatly reduced HR in post stress recovery period (P<0.05 for all). In anesthetized animals, BPP‐10c did not change sympathetic tone sampled from renal nerve. We conclude that BPP‐10c has central effects, modulating behavior and improves recovery of homeostasis after acute stress exposure. Support: CNPq, FAPEMIG and FAPESP.