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Electroacupuncture Improves Left Ventricular Dysfunction and Arrhythmia in a Rabbit Model of Prolonged Ischemia/Reperfusion
Author(s) -
Zhou Wei,
Ko Yoshihiro,
Patel Sunny,
Mahajan Aman
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.809.16
Subject(s) - medicine , cardiology , ischemia , myocardial infarction , electroacupuncture , norepinephrine , microdialysis , anesthesia , left coronary artery , dopamine , alternative medicine , pathology , acupuncture
Augmentation of cardiac sympathetic tone during myocardial ischemia has been shown to increase myocardial oxygen demand, arrhythmias, and infarct size in animal models. We previously demonstrated that electroacupuncture (EA) inhibits the visceral sympathoexcitatory cardiovascular reflex. The purpose of this study was to determine the effects of EA on left ventricular (LV) mechanics, oxygen demand, arrhythmias, infarct size and in vivo cardiac norepinephrine release in rabbits with myocardial ischemia and reperfusion (MIR). Anesthetized rabbits underwent 60 min of left coronary artery (LCA) occlusion followed by 3 h of reperfusion. We evaluated the LV twist by 2D speckle tracking imaging, elevated ST segments of electrocardiogram (ECG), ventricular arrhythmias, infarct size, and myocardial norepinephrine release by cardiac microdialysis under three experimental conditions: 1) control, 2) EA at P 5–6 acupoints, and 3) EA at nonacupoints. MIR decreased the LV twist and increased ventricular arrhythmias, elevation of ST segments, infarct size, and oxygen demand as well as the concentrations of myocardial norepinephrine. EA at P 5–6 significantly attenuated the deleterious effects of MIR, while EA at nonacupoints had no effects. These data suggest that EA produces cardioprotective effects against MIR through an inhibition of cardiac sympathetic nervous system. Supported by AHA BGIA‐0765001Y.