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Muscular Efficiency in Highly‐Trained Type 1 Diabetic Subjects
Author(s) -
Cassuto Nicholas A.,
Wong Eric C.,
Baldi James C.,
Wheatley Courtney M.,
FoxxLupo William T.,
Snyder Eric M.
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.806.23
Subject(s) - medicine , endocrinology , type 1 diabetes , diabetes mellitus
Type 1 diabetes (T1DM) is associated with impaired vascular function and ability of the muscle to utilize glycogen as a fuel source. We examined muscle efficiency (ME) during exercise between 12 highly‐trained T1DM subjects and 10 matched healthy subjects (age=33±8 vs. 40±8yrs, ht.=180±11 vs. 181±9cm, weight=74±11 vs. 74±9kg, VO2peak=123±19 v 126±22% pred., for healthy and T1DM, mean±SD). We measured power output and VO2 across the groups during 4 workloads (wkld 1=79±13 vs. 78±13watts, relative work=33±4 vs. 32±4%peak, VO2=1610±272 vs. 1670±354ml/kg/min; wkld 2=119±19 vs. 116±20watts, relative work=49±7 vs. 47±6%peak, VO2=1976±270 vs. 2015±363ml/kg/min; wkld 3=158±26 vs. 155±27watts: relative work=66±9 vs. 63±7%peak, VO2=2417±417 vs. 2383±397ml/kg/min; and wkld 4=198±32 vs. 193±34watts, relative work=82±11 v 78±9%peak, VO2=2794±490 vs. 2628±537ml/kg/min, for healthy and T1DM). ME was higher in T1DM (ME 1= 20.8±3.2 vs. 27.2±8.3, ME 2 = 22.7±2.4 vs. 26.7±6.4, ME 3 = 23.3±2.8 vs. 26.6±4.3, ME 4 = 24.0±2.6 vs. 28.5±3.5, for healthy and type 1 diabetics). Change in ME was then calculated (Δeff 1=43.3±25.9 vs. 101.1±157.9%, Δeff 2=39.8±38.4 vs. 27.0±4.8%, Δeff 3=38.8±48.4 vs. 30.1±9.7%, Δeff 4=29.1±7.7 vs. 43.8±24.4%). These results suggest that highly‐trained T1DM subjects demonstrate a higher ME during exercise, possibly due to differences in substrate utilization between these groups.