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Effects of Exercise Training on Biomarkers of Endothelial Function and Inflammation in Coronary Artery Disease Patients
Author(s) -
Ribeiro Fernando,
Alves Alberto J,
Teixeira Madalena,
Miranda Fátima,
Duarte José A,
Oliveira José
Publication year - 2010
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.24.1_supplement.806.20
Subject(s) - medicine , inflammation , endothelial dysfunction , c reactive protein , coronary artery disease , aerobic exercise , cell adhesion molecule , endothelium , gastroenterology , myocardial infarction , immunology
Purpose to assess the effects of exercise training on biomarkers of endothelial function and inflammation. Methods 47 patients after acute myocardial infarction were randomized to an exercise‐training group (ETG) receiving an 8‐week aerobic exercise programme (3× per week) or to a control group (CG) receiving usual care. At baseline and after 8 weeks the circulating levels of soluble intercellular adhesion molecule‐1 (sICAM‐1) and vascular cell adhesion molecule‐1 (sVCAM‐1), C‐reactive protein (CRP), interleukin (IL)‐6 and ‐10 were assessed. Results ETG increased the circulating levels of IL‐10. Conversely, CG did not change the inflammatory biomarkers, but increased the endothelial dysfunction ( Table 1). 1 Changes in the inflammatory and endothelial function biomarkers [median (percentile 25 th –75 th )]ETG CGBaseline Final Baseline FinalCRP (mg/L) 1.1 (0.5–2.2) 1.4 (0.5–2.4) 0.9 (0.5–1.7) 0.9 (0.7–1.9) IL‐6 (pg/mL) 2.5 (1.6–3.2) 3.13 (2.1–5.0) 3.6 (1.7–6.5) 3.5 (2.8–4.7) IL‐10 (pg/mL) 5.8 (2.6–9.1) 6.36 (4.1–14.7) † 7.7 (4.4–17.2) 7.3 (2.9–10.2) sICAM‐1 (ng/mL) 169 (143–209) 187 (154–201) 180 (147–219) 206 (169–242) † sVCAM‐1 (ng/mL) 297 (223–377) 340 (269–418) 245 (179–304) 341 (231–424) †† Different from baseline, P<.05Conclusions Exercise‐training revealed an anti‐inflammatory effect, expressed by the IL‐10 increase, and counteracted the endothelial function deterioration.